Nikolaos.Koutsouleris@med.uni-muenchen.de
The current taxonomic systems in psychiatry often group a wide range of symptoms under broad diagnostic categories, leading to significant heterogeneity within each disorder and across different disorders. This heterogeneity obscures the underlying biological and environmental factors that contribute to mental illnesses, making it difficult to identify early signs of disease pathology. Consequently, clinicians face challenges in applying uniform treatment approaches, as the diverse symptom profiles require more nuanced interventions. Deconvolving this heterogeneity—by dissecting the complex layers of symptoms and their origins—could enable the development of more precise diagnostic tools. Ultimately, a more refined classification system would pave the way for early detection and personalized treatment strategies, improving outcomes for individuals with mental disorders. Our lab is at the forefront of precision psychiatry, harnessing cutting-edge neuroimaging, genomics, and computational modeling techniques to decode the complexities of mental health and drive the development of tailored clinical solutions.
I serve as consultant in Transitional Youth Mental Health and hold a Chair in Precision Psychiatry at Ludwig-Maximilians-University and King’s College London and the Max Planck Institute (MPI).
For the last 20 years I have dedicated my research work to develop and leverage advanced machine learning and neuroimaging techniques to improve early diagnosis and personalized treatment strategies for affective and non-affective psychoses. By integrating neurobiological, neurocognitive, and clinical data, my work aims to enable effective risk stratification, predictive modelling, and improved diagnostic clarification of psychiatric disorders. I have pioneered methods to translate complex multivariate analyses into actionable tools for routine clinical care.
Christopher.Eberle@med.uni-muenchen.de
Chris holds a PhD in Medical Research focusing on brain circuitry alterations in psychotic and affective disorders. At LMU Klinikum, he supports the early recognition outpatient service and works on early detection tools for individuals at high risk for psychosis.
Keywords: diagnostics, psychosis, risk, clinical presentation, MRI, personality
L.Hahn@med.uni-muenchen.de
Lisa holds a PhD in Medical Sciences, MSc in Cognitive and Clinical Neuroscience with a specialization in Neuropsychology, and BSc in Psychology. Her research focuses on mechanistic precision psychiatry, integrating neuroimaging data (sMRI, fMRI) with neurotransmitter distribution maps to investigate the underlying biology of psychotic disorders, particularly schizophrenia. An additional line of research explores the role of thyroid-stimulating hormone (TSH) in the pathophysiology of psychotic disorders. She is also part of the NeuroMiner development team.
Keywords: machine learning, neuroimaging, sMRI, fMRI, neuromapping (JuSpace), BrainAGE
Ariane.Wiegand@med.uni-muenchen.de
Ariane holds a PhD in Neuroscience, MSc degrees in Neural and Behavioural Sciences and Bioinformatics, and a BSc in Molecular Medicine. She focuses on interpretable machine learning for psychiatry. Her work includes NeuroMiner development, multi-omics data analysis, and enhancing clinical applications of predictive models for mental health.
Keywords: interpretable machine learning, genetics, epigenetics, omics, neuroimaging
david_popovic@psych.mpg.de
David holds an MD and PhD from LMU. He serves as a Senior Physician in the Department of Forensic Psychiatry and is actively involved in supervising MD/PhD students. His research focuses on the development of the SPLS Toolbox and supports forensic evaluations and data science consultations through the POKAL College. Additionally, he is a Young Scientist Coordinator for the planned German Center for Mental Health (DZPG).
Maria.Urquijo@med.uni-muenchen.de
Mafe holds PhD and a MSc in Neuro-Cognitive Psychology from LMU. She has been actively involved in the collection of PRONIA data, and she is involved in the early recognition outpatient service at LMU Klinikum. Her research focuses on sex differences and multimodal data integration in the early psychiatric spectrum, with the goal of improving women’s mental health.
Keywords: sex differences, machine learning, schizotypy, multimodal data, women’s mental health, PRONIA, early recognition
Julia.Fietz@med.uni-muenchen.de
Julia Fietz holds a PhD in Medical Research as well as an MSc and BSc in Psychology. She is currently in training as a cognitive behavioral therapist. Her research focuses on the integration of multimodal data—including neuroimaging, psychophysiology, genetics, and neurocognition—with clinical information to improve the understanding and prediction of mental health outcomes. A key area of her work is the use of machine learning techniques to enhance the prediction of suicidal risk in young adults.
Keywords: Multimodal Machine learning, Neuroimaging, transdiagnostic approaches, suicidal risk
Grace.Jacobs@med.uni-muenchen.de
Grace holds a PhD in Medical Science, with a specialty in Neuroscience from the University of Toronto. Her research focuses on trajectories of early psychotic symptoms and overlapping psychopathology (e.g., depression, autistic traits) and uses machine learning and neuroimaging to identify predictive biomarkers of illness and provide insight into underlying neurobiology and associated risk factors. A key area of her work involves investigating childhood trauma, and how types of trauma impact trajectories of mental illness and neurobiology. Grace is an affiliated research fellow at the Artificial Intelligence in Mental Health Lab at King’s College London and recipient of the Canadian Institutes of Health Research Banting Postdoctoral Fellowship.
Keywords: MRI, psychosis, trajectories, youth mental health, clinical high risk for psychosis, machine learning
Yuki.Tiebel@med.uni-muenchen.de
Yuki holds a B.Sc. in Clinical Developmental Psychology, an M.Sc. in Neuro-Cognitive Psychology, and a Ph.D. in Brain Stimulation & MRI under the supervision of Prof. Padberg and Dr. Keeser. Yuki is responsible for MRI scanning and for collecting data for the Biobank.
Keywords: depression, neuroimaging, MRI, brain stimulation, TMS, tDCS, concurrent TMS-fMRI, biobank, clinical data management, biomedical data integration, digital health infrastructure
madalinaoctavia.buciuman@med.uni-muenchen.de
Madalina holds a M.Sc. in Neuro-Cognitive Psychology. She previously worked on cognitive neuroscience projects focusing on affective and perceptual processes in relation to psychopathology. Her PhD project investigates the use of state-of-the-art resting-state fMRI and multimodal brain measures for outcome prediction and subtyping in early psychiatric disorders. Madalina is involved in data management, MRI pipeline development, ViPAR administration, and leads the HARMONY project.
Keywords: psychosis, fMRI, sMRI, machine learning, prognosis, subtyping, functioning outcomes
alessa.grund@med.uni-muenchen.de
Alessa holds a M.Sc. in Biomedical Computing and a B.Sc. in Cognitive Science. Specialized in machine learning for medical imaging, her current research focuses on identifying multimodal predictors of symptom distress in clinical high-risk patients to improve understanding and outcomes. She serves as IT coordinator for the CARE clinical study and manages the technical maintenance of the PRONIA AI psychosis risk-prediction algorithm.
Keywords: early intervention, symptom-related stress, multimodal machine learning, neuroimaging, psychosis risk
Liisi.Promet@med.uni-muenchen.de
Liisi Promet earned her B.Sc. in Biology from the University of Tartu, Estonia, and her M.Sc. in Neuroscience from the International Max Planck Research School in Göttingen, Germany. She is interested in disentangling the biological heterogeneity in psychosis from the clinical high-risk state to established schizophrenia. Her current projects include a systematic review on biological subtypes in schizophrenia, predicting conversion to psychosis using proteomics data, and investigating the longitudinal course and treatment response in neuroanatomical subtypes of schizophrenia.
Keywords: schizophrenia, psychosis, heterogeneity, subtyping
Elif.Sarisik@med.uni-muenchen.de
Elif Sarisik is a medical doctor with a degree from Istanbul University. Her research includes developing machine learning approaches to identify EEG-based signatures of schizophrenia, depression, and aberrant brain aging, as well as predicting risk factors for mental disorders in transdiagnostic populations. Her work emphasizes the integration of multimodal data, such as EEG and phenomenological analyses, to advance predictive and preventive psychiatric interventions.
Keywords: EEG, schizophrenia, machine learning, transdiagnostic, sparse partial least squares (SPLS)
Clara.Vetter@med.uni-muenchen.de
Clara is a PhD candidate specializing in machine learning to analyse multimodal data (including neuroimaging, genetics, childhood trauma, and behaviour), e.g., to identify transdiagnostic risk and resilience signatures for psychiatric disorders and predict disease outcomes. Additionally, she contributes to the development of the NeuroMiner toolbox and organisation of the NeuroMiner summer school. Clara holds an MSc in Psychology & Behavioural Data Science from the University of Amsterdam, with experience from international research collaborations and IT start-ups.
Keywords: multimodal machine learning, network analysis, subtyping, genetic and environmental risk for psychosis, childhood trauma
clara.weyer@med.uni-muenchen.de
Clara is a PhD candidate with a background in psychology (University of Freiburg) and biomedical neuroscience (TU Munich). Her research focuses on applying multivariate approaches to investigate transdiagnostic biological and clinical signatures of early-stage mental health disorders, with a particular interest in blood-based biomarkers. Clara is also a member of the clinical team, working in the early recognition service of the clinic, thereby bridging the translational gap between research and clinical practice.
Keywords: psychosis risk, depression, translational, transdiagnostic, clinical diagnostics, blood marker, inflammation, sparse partial least squares (SPLS), childhood trauma
John.Fanning@med.uni-muenchen.de
John earned his BA in Psychology at the University of Colorado – Boulder and his MSc in Neuro-cognitive Psychology at the Ludwig-Maximilians-University Munich. He is a PhD candidate with a particular focus on schizotypy and its relationship with neuroimaging, including structural and resting-state modalities. He also works as part of the group’s early recognition service for the ProNET project.
Keywords: depersonalization, derealization, schizotypy, sparse partial least squares (SPLS), sMRI, rs-fMRI, gyrification
Maria.Sacha@med.uni-muenchen.de
Maria holds a MD from the National and Kapodistrian University of Athens and a MSc in Biomedical Engineering from Université de Paris – PSL – Arts et Métiers (BMEParis), while she has prior experience in computational neuroscience. She is a PhD candidate of the International Max Planck Research School for Translational Psychiatry, studying deep mechanistic modeling of treatment response in psychosis as part of the European Virtual Brain Twins project.
Keywords: recent onset psychosis, symptom trajectories, virtual brain twins
Daniel.Weinert@med.uni-muenchen.de
Daniel holds a MSc in Neurocognitive Psychology and a BSc in Psychology from LMU Munich. He combines approaches from general psychology and attention research with neuroscientific methods and machine learning. His PhD project investigates the plasticity of the visual system in healthy people and those suffering from inherited retinal diseases. He employs a multimodal approach using MRI, fMRI, EEG, behavioural, and ophthalmologic data to create novel models to measure vision function and that can be used to predict vision development and treatment success for novel treatments of inherited retinal diseases.
Keywords: Visual perception, attention, neural plasticity, inherited retinal disease, IRD, MRI, fMRI, EEG
Nathalie.Matti@med.uni-muenchen.de
Nathalie holds a MD from Lund University and is a PhD candidate with a research focus on neuroanatomical structure and clinical subtypes in Frontotemporal Lobar Degeneration and their interphase with primary psychiatric disorders. In addition to her research, she is a resident doctor in Psychiatry at LMU Klinikum.
Keywords: frontotemporal lobar degeneration, FTD, neuroanatomical signatures, sMRI
Renata.De@med.uni-muenchen.de
Renata holds both a M.Sc. in Computer Science from the University of Campinas, Brazil, and a B.Sc. in Computer Science from the São Paulo State University, Brazil. With a background in machine learning and deep learning, her current research focuses on investigating differences in structural and functional MRI patterns related to auditory verbal hallucinations in patients with mental disorders. She serves as the Coordinator of the Multicenter Collaborative Study of the German Center for Mental Health (DZPG) and the Medical Informatics Initiative (MII), where she also leads data and IT management tasks. Additionally, she is responsible for the IT and data management within our working group.
Keywords: data management, IT management, data quality assurance, project coordination, data science, machine learning
Richard.Gaus@med.uni-muenchen.de
Richard holds an MD from Charité Berlin and is currently pursuing an M.Sc. in Robotics, Cognition, and Intelligence at TU Munich. He is training in psychiatry at LMU Klinikum, where he supports the early recognition outpatient clinic. His research focuses on applications of large language models in psychotherapy and mental healthcare, with the goal of improving the accessibility and reach of behavioral health services.
Keywords: deep learning, large language model, natural language processing, cognitive behavioral therapy, clinical reasoning
Lenka.Krcmar@med.uni-muenchen.de
Dr. Lenka Krcmar holds an MD and a PhD in Medical Research with a focus on Translational Psychiatry from the International Max Planck Research School in Munich. She is currently undergoing specialty training in psychiatry at LMU Klinikum.
She is involved in a research project aimed at uncovering multivariate associations between brain structure and function and cognitive performance in individuals with recent-onset psychosis (ROP). Identifying neurobiological correlates of cognitive functioning may support early diagnosis, improve prognostic accuracy, and inform personalized treatment strategies.
Keywords: recent onset psychosis, cognitive disturbances (COGDIS), sparse partial least squares (SPLS), multivariate analysis, sMRI
Nikos.Diederichs@med.uni-muenchen.de
Nikos studies medicine at LMU Munich. His current research focuses on computational MRI-based subtyping of depressive disorders using machine learning methods. As an MD student in the FöFoLe-Program, an elite research training program of the LMU Faculty of Medicine, he specializes in data management and preprocessing of neuroimaging and clinical datasets, developing MATLAB-based workflows for the lab's research cohorts.
Esther holds a PhD in Signal Processing, along with a B.Eng. and M.Eng. in Audiovisual Systems and Multimedia Communications. Her current research focuses on developing generalizable, fair, and interpretable Deep Learning models to predict transition to psychosis in clinical high-risk patients.
Personal Website / Contact: https://erituert.github.io/
Keywords: machine learning, deep learning, transformers, computer vision, mental health, smri
J.Trott@med.uni-muenchen.de
Jana holds an MD from LMU & TU Munich and an M.Sc. in Neuroscience from King’s College London. She trains in child and adolescent psychiatry and currently supports the early recognition service at LMU. In her research, she employs transdiagnostic and multimodal machine learning approaches to identify early markers of psychiatric disorders at different developmental stages, eventually aiming to facilitate timely and targeted interventions in youth mental health.
Keywords: youth mental health, adolescence, transdiagnostic, prevention, early intervention
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Adyasha recently completed her PhD at LMU Klinikum as part of the International Max Planck Research School for Translational Psychiatry. She holds a BS-MS in Biology from Indian Institute of Science, Education and Research, Kolkata, India. Her research focused on the biological underpinnings of somatic comorbidities within psychiatric diseases. She developed clinically useful tools for comorbidity-informed patient stratification using various data modalities including neuroimaging, clinical, and genetic data and employing robust machine learning methods. Adyasha was also actively involved in managing, harmonizing, and analyzing large-scale multi-site data from the ECNP Neuroimaging Consortium.
Mark Sen Dong is a senior machine learning engineer and full-stack software developer with expertise in AI-driven mental health solutions. He completed his Ph.D. at LMU Klinikum, where his research focused on applying machine learning to precision psychiatry, optimizing prediction models for psychiatric disorders, and developing clinically applicable AI tools. As the lead developer of multiple mental health web applications, including Elsa Health and the NM Model Library, Mark has contributed to advancing AI integration in psychiatry. He continues to work at the intersection of AI, mental health, and software development through his consultancy, Gefyra AI Technologies, aiming to bridge the gap between research and real-world applications.
Mark's company website: https://gefyra.ai